Minocycline: the end of the road? - HDBuzz - Huntington’s disease research news
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چکیده
The DOMINO study group has published the report of its ‘futility study’ of minocycline treatment in HD. Minocycline and a placebo pill were tested over 18 months. A futility study is designed to make it relatively easy for a drug to be recommended for larger studies, but minocycline treatment wasn’t promising enough and the study authors found that further trials with minocycline were “not warranted”.
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NUB1: enhancing clearance to decrease mutant huntingtin - HDBuzz - Huntington’s disease research news
Getting to the NUB of the matter Everyone has two copies of the huntingtin gene (the recipe for the huntingtin protein, if you like). Patients with Huntington’s disease (HD), however, have one extra-long copy of the huntingtin gene, caused by a mutation, or misspelling in the genetic code. This means that in addition to the normal version of the huntingtin protein, HD patients also produce its ...
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